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KMID : 0385520100230010097
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Analytical Science & Technology
2010 Volume.23 No. 1 p.97 ~ p.101
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1Determination of optical purity of N-acetyl-1-naphthylethylamine by chiral chromatography and NMR spectroscopy
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Jeong Young-Han
Ryoo Jae-Jeong
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Abstract
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(R)-N-3,5-dinitrobenzoyl (DNB) phenylglycinol derived chiral selector was used as a HPLC chiral stationary phase (CSP) for the resolution of racemic N-acylnaphthylalkylamines. In this study, determination of optical purity was performed by both chiral chromatography and NMR spectroscopy by using the (R)-phenylglycinol derived chiral selector. The data of accuracy and precision of each optical purity value are calculated from the results of NMR and HPLC experiments by comparing with true value. Average error of the NMR method was +2.2% with average RSD of 4.54%, while that of HPLC method was -3.5% with average RSD of 3.23%.
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KEYWORD
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chiral selector, HPLC, N-acylnaphthylalkylamines, optical purity, NMR
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